CIAS Trial

CIAS Trial. Means a Phase IIa trial aimed at treating cognitive impairment associated with schizophrenia, which Phase IIa trial (a) tests multiple doses of Compound 3454, (b) is placebo-controlled and double-blinded, (c) requires dosing per patient based on a treatment plan with a period of a minimum of 8 weeks in duration, (d) includes a minimum of 212 patients randomized (3 dose groups and 1 placebo group [*]) or less than 212 patients if requested in writing by Roche, (e) has as its primary goal an... assessment of cognition based upon MATRICS, (f) uses secondary outcome measures in two areas: general psychopathology (positive and negative symptoms of schizophrenia; depression) and social competence, and (g) includes smokers and non-smokers. Roche shall have the right, in its sole discretion, to direct Memory in writing to terminate enrollment of new patients in the CIAS Trial at any point for any reason; and Memory shall comply with such request as soon as reasonably possible. For the avoidance of doubt, it is understood and agreed that the actual achievement of [*] CONFIDENTIAL TREATMENT IS REQUESTED [*], as described in (d) above, is not required in order for such trial to constitute the CIAS Trial. View More