Required Preferred Directors

Required Preferred Directors. Means (a) for as long as the directorship to be filled by the Series B Director remains vacant, the approval of a majority of the Series A Directors designated by Pfizer, Inc., Bain and OrbiMed, and (b) if the directorship to be filled by the Series B Director is no longer vacant, the approval of a majority of (i) the Series A Directors and (ii) the Series B Director, voting together as a group.