Major Investor

Major Investor. Means each of Baker Brothers Life Sciences, L.P. and its Affiliates, including 667, L.P. (collectively, "BBA"), OrbiMed Private Investments VI, LP and its Affiliates (collectively, "OrbiMed"), Krishna Vaddi, Dolphin City Trust, Sidus Ventures, LLC and each Fidelity Investor.

Major Investor. Means any Investor that, individually or together with such Investor's Affiliates, holds at least (i) 1,681,131 shares of Preferred Stock (as adjusted for any stock split, stock dividend, combination, recapitalizations, reclassifications and the like effected after the date hereof) or (ii) such number of Registrable Securities issued or issuable upon conversion of 1,681,131 shares of Preferred Stock (as adjusted for any stock split, stock dividend, combination, recapitalization,... reclassification and the like effected after the date hereof) provided that each RA Capital Investor shall be deemed to be a Major Investor for so long as each such RA Capital Investor holds the number of shares purchased by such RA Capital Investor under the Purchase Agreement, and provided further that, notwithstanding the foregoing, in the event that any Major Investor becomes a Defaulting Purchaser (as defined in the Purchase Agreement), such Defaulting Purchaser shall cease to be a Major Investor under this Agreement. View More

Major Investor. Means any holder of Preferred Shares that, individually or together with such Investor's Affiliates, owns at least 2,200,000 shares of Registrable Securities derived from such Preferred Shares, as adjusted for any share split, share dividend, combination, or other recapitalization or reclassification effected after the date hereof.

Major Investor. Means any Investor that, individually or together with such Investor's Affiliates, holds at least (a) 20,000,000 shares of Common Stock issuable or issued upon conversion of the Series A Preferred Stock and/or (b) 1,000,0000 shares of Common Stock issuable or issued upon conversion of the Series B Preferred Stock, both as adjusted for any stock split, stock dividend, combination, or other recapitalization or reclassification effected after the date hereof, held by such Investor on the date... hereof. View More

Major Investor. Any Investor that, individually or together with such Investor's Affiliates, holds at least 2,000,000 Common Shares issued or issuable upon conversion of Preferred Shares (as adjusted for any stock split, stock dividend, combination, or other recapitalization or reclassification effected after the date hereof); provided that a Defaulting Investor shall not be considered a Major Investor hereunder.

Major Investor. Means any Investor holding shares of Preferred Stock with an aggregate Original Issue Price (as defined in the Certificate of Incorporation) of at least $1,000,000.

Major Investor. Means (a) any Investor that, individually or together with such Investor's Affiliates, holds at least (i) 1,500,000 shares of Preferred Stock or (ii) at least 859,874 shares of Series C Preferred Stock (such shares in (i) and (ii) as adjusted for any stock split, stock dividend, combination, or other recapitalization or reclassification effected after the date hereof) and (b) AstraZeneca AB ("AstraZeneca"), for so long AstraZeneca and its Affiliates continue to own beneficially any shares of... Preferred Stock. View More

Major Investor. Means any Investor that, individually or together with such Investor's Affiliates, holds an amount of Registrable Securities representing an investment into the Company in an aggregate amount of at least $5,000,000.

Major Investor. Means any Investor that, individually or together with such Investor's Affiliates, holds at least 571,429 units of Registrable Securities (as adjusted for any unit split, distribution, combination, or other recapitalization or reclassification effected after the date hereof), and Mayo Clinic.

Major Investor. Means any Investor that, individually or together with such Investor's Affiliates, holds at least 1,142,361 shares of Registrable Securities then outstanding (as adjusted for any stock split, stock dividend, combination, or other recapitalization or reclassification effected after the date hereof); provided, however, that Blackwell Partners LLC—Series A shall also be deemed to be a Major Investor for so long as Blackwell Partners LLC- Series A continues to hold 336,967 shares of Series B... Preferred Stock, and provided that Roche shall also be deemed to be a Major Investor for purposes of Section 3.1 herein. View More